763 Expanded and activated TILs kill tumor cells enabling IO compound assays
نویسندگان
چکیده
منابع مشابه
OK432-activated human dendritic cells kill tumor cells via CD40/CD40 ligand interactions.
In vivo, dendritic cells (DC) are programmed to orchestrate innate and adaptive immunity in response to pathogen-derived "danger" signals. Under particular circumstances, DC can also be directly cytotoxic against tumor cells, potentially allowing them to release tumor associated Ags from dying cells and then prime antitumor immunity against them. In this study, we describe the innate characteri...
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Introduction The combined modalities of chemotherapy, radiotherapy, and surgery have had a significant impact on cancer mortality. Still, nearly 50% of the adult victims of cancer die of their disease as a result of primary or acquired resistance (1 ). The enormously diverse immune system, able to generate specific soluble and cell-mediated responses to as many as lO ligands, has had strong int...
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We determined whether the multi-kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over-expressed in liver tumors compared to normal liver tissue. In multiple cell types in vitro sorafenib/regorafenib and PDE5 inhibitors interacted in a greater than additive fashio...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2020
ISSN: 2051-1426
DOI: 10.1136/jitc-2020-sitc2020.0763